3D Bioprinting Solutions
3D Bioprinting Solutions is a Laboratory for Biotechnological Research founded by INVITRO, the largest private medical company in Russia. The laboratory develops and produces bioprinters and materials for 3D bioprinting, and also develops innovative technologies in the field of biofabrication.
An international multi-disciplinary team of researchers, world-class scientists, engineers and management was assembled for this new laboratory. Vladimir Mironov, one of the recognized pioneers of robotic biofabrication, Professor of the Department of Chemical and Life Science Engineering at Virginia Commonwealth University (USA), became the laboratory’s Head of Research.
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FABION 2 is the next generation top-ranked bioprinter able to print complex structures using tissue spheroids and a wide range of hydrogels with different types of polymerization: thermosensitive hydrogels, multi-component hydrogels, photosensitive, Ph-sensitive and ionic-sensitive hydrogels.
Novel 3D bioprinter which enables rapid label-free 3D biofabrication of 3D tissue and organ constructs in the condition of microgravity using magnetic fields. Using microgravity as a co-factor of bioprinting technology allowed us to apply scaffold-free, nozzle-free, and label-free (without using magnetic nano-particles) approach so called “formative” biofabrication which has the edge over classical bottom-up additive manufacturing.
3D bioprinter «Organ.Aut» is a part of ISS scientific equipment which allows any scientific groups and companies interested in the 3D bioprinting technology to conduct international experiments.
Viscoll is our new line of versatile collagen products suitable for any 3D bioprinter. It provides life science companies, researchers and innovators working in biofabrication with a powerful tool which offers unprecedented capabilities in experiments.
tel: +7 (499) 769-50-18
Bioink Solution, Inc.
Bioink Solution, Inc. was established to develop and provide the biofabrication community with standardized bioinks that are optimally formulated for bioprinting of cells, tissues and organs to assist researchers accelerate translation of their innovative technologies.
Our mission is to contribute to the advancement of bioprinting/ biofabrication field with a vision of revolutionizing the current medical practices to achieve total CURE.
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Technologies and Products:
Bioink Solution, Inc. provides hydrogel-based bioinks (Gel4Cell®) for cell-based 3D bioprinting and polymer-based bioinks (PolyInks®) for structure-based 3D bioprinting.
Gel4Cell® Bioink, Basic Formulation You Can Trust and Print with Confidence!
The Bioink Solution’s Gel4Cell® formulation has been tested to generate multiple layered 3D tissue constructs that maintain structural integrity over a long-term in vitro.
Although Gel4Cell® bioink is specifically formulated for bioprinting applications, it can be used for other research studies that require 3D culture environment.
Gel4Cell®-Peptide Bioinks for Tissue-specific Regeneration!
The Bioink Solution’s Gel4Cell®-Peptide bioink formulations are conjugated with tissue-specific growth factor-mimetic peptides for cell-based 3D bioprinting.
The peptide bioinks available currently include Gel4Cell®-BMP, Gel4Cell®-TGF and Gel4Cell®-VEGF.
TGel®-S -Tissue-derived Bioinks for Enhanced Regeneration!
TGel®-S bioink formulations derived from pig small intestinal submucosa (SIS) can support cell proliferation and accelerate maturation/formation for various tissue engineering applications.
TGel®-S bioink contains collagen, glycosaminoglycans (GAGs), hyaluronic acid, heparan sulfate, chondroitin sulfate, and growth factors such as FGF-2 and TGF-β.
Jang-Soo Suh, MD, PhD, CEO
Bioink Solution, Inc. seeks collaboration and partnership with academia and industry worldwide to co-develop new and innovative bioinks for commercialization
CollPlant (NASDAQ:CLGN) is a regenerative medicine company focused on developing and commercializing BioInks for 3D bioprinting and tissue repair products. CollPlant’s products are based on its recombinant human collagen (rhCollagen) which is produced in genetically engineered tobacco plants using CollPlant’s proprietary technology. The Company’s products, which address 3D bioprinting, medical aesthetics, orthopedics and advanced wound care, are ushering in a new era in regenerative medicine. Commercialization of CollPlant’s three lead products including BioInk, VergenixSTR for tendon repair, and VergenixFG for wound care, was initiated in 2017. They address multi-billion dollar markets worldwide.
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We strive to be the leading company in the field of regenerative medicine by delivering innovative products that offer the best treatment options to patients and their physicians.
CollPlant’s technology is the only commercially viable technology currently available to produce true Type I human collagen. Collagen is an essential building block of the human body, providing structural support and biological signals to connective tissues and organs, and therefore it is a crucial component for tissue regeneration. CollPlant’s proprietary technology includes the introduction into tobacco plants, of 5 human genes that are essential for the synthesis of Type I collagen. The tobacco plant then proceeds to yield human collagen that is superior to the collagen(s) currently in the market, sourced from animals, or even human cadavers. rhCollagen is identical to natural human collagen, therefore it does not elicit an immune response in humans. Its plant origin yields a safe product with more consistent properties, making it the ideal building block/scaffolding molecule for regenerative medicine. CollPlant’s rhCollagen is a broadly applicable technology platform that is cost effective and enables products for medical uses with superior biological and physical properties.
- BioInks for 3D Bioprinting of Tissues and Organs: Recently, 3D bioprinting has been gaining momentum in many medicinal applications to address the need for complex scaffolds needed for generation of tissues and organs suitable for transplantation. CollPlant’s rhCollagen-based BioInks are ideal for 3D bioprinting due to their safety profile, as well as their biological and physical properties. rhCollagen enables an unlimited, economical supply of organs around the world. Currently, 3D bioprinting is primarily used in R&D, as the technology is moving towards commercialization of manufactured lifesaving organs including lungs, liver, kidney and heart. United Therapeutics (UTHR), a leader in the field, has entered a licensing agreement with CollPlant, valued at up to $44 M plus royalties, for use of CollPlant’s BioInks for the manufacture of lungs. The ability to manufacture organs could save nearly a million lives in the U.S. alone, where 30,000 organ transplants are done each year and 900,000 people die every year due to organ impairment.
- Advanced Wound Care and Orthobiologics: CollPlant serves the $6.7 B Orthobiologics market with its soft tissue repair product, VergenixSTR. The product is designed for the treatment of tendinopathy, accounting for over 3 million procedures per year in the US alone. Advanced wound care treatment is a $6.2 B market which CollPlant serves through its VergenixFG product, a wound filler for acute and chronic wounds. The size of the target market for Vergenix products is approximately $5 B. Both products were recently launched in Europe and CollPlant is currently working on filing for FDA approval in the U.S.
Yehiel Tal firstname.lastname@example.org
“Aging is a Disease” and “Nature is Prescription”
ROKIT Healthcare strives to resolve the global aging problem through organ regeneration and compression of morbidity. We make every effort for a better quality of life for the humanity.
ROKIT Healthcare is a global healthcare company committed to providing the safest and most effective autologous organ regeneration platform using its proprietary biofabrication technologies across all types of applicable diseases in the field of regenerative medicine.
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Through a convergence of know-how’s and innovation in the areas of R&D (i.e. 3D bioprinting, autologous stem cell technologies, and human-derived biomaterials), surgical medicine, and regulatory affairs, ROKIT Healthcare believes in supplying customized organ regeneration platform services that will drastically change the way we trust and manage the health of our own body.
ROKIT was founded in 2012 by Seok Hwan You as a 3D printing technology company. From 2013 to 2015, the company released several desktop 3D printer lines for applications in educational training, fashion, design, food and industrial manufacturing.
In April 2016, the company entered the biomedical industry with the launch of INVIVO, a cell and biomaterial 3D printer equipped with clean chamber technology. It is one of the first commercialized desktop bioprinters made in Korea.
In addition to being a printer manufacturer, ROKIT works as a medical contractor that partners with state agencies, biotechs and academic research centers to develop applications of the 3D bioprinting technology in the hospital operating room.
In October 2016, ROKIT was awarded a $3 million grant by the South Korean government to co-develop an in-situ 3D bioprinting system for skin regeneration. In Dec 2017, ROKIT announced the establishment of a European R&D center in Germany as a research collaborator with Fraunhofer IBMT. In 2018, ROKIT signed agreements with plastic surgery clinic GNG in Korea to develop processes and technology to create 3D printing-guided regeneration of skin and cartilage tissues for use in nose and ear reconstruction. In 2019, ROKIT Healthcare has won $30 million worth of investment, and is striving toward the development and launching of new therapies in regenerative medicine.
Mission & Vision:
ROKIT envisions to change the world by serving patients through personalized regenerative therapies with our customized artificial organ platforms.
- Technologies to be highlighted:
ROKIT is developing platform services in the areas of Dermatology, Orthopedics, Cardiology, and Ophthalmology (skin regeneration, cartilage regeneration, heart patch regeneration, retina regeneration, and hair regeneration.) ROKIT will provide organ regeneration platforms that combine a device, materials, and surgical protocols in a ready-to-use package in the operating room.
For the R&D sector, ROKIT Healthcare offers technologies in 3D biofabrication and biomaterial development using the cell sheet technology.
ROKIT Healthcare offers INVIVO, a polymer and hydrogel extrusion 3D printer equipped with built-in sterilization systems, which allows researchers to fabricate soft and hard 3D biological structures with cells.
ROKIT Healthcare also offers whole extracellular matrix (ECM)-based bioink supplements, developed using the cell sheet technology. The technology employs cells on a polymer bed of tunable stiffness mimicking anywhere from soft to hard microenvironments. This allows the production of human cell-derived ECM with the native architecture of the matrix retained and customizable to various tissues.
INVIVO: Made by Nature. Healthcare Innovation by INVIVO.
INVIVO was developed for biomedical researchers and material engineers to pattern cells, biomolecules, and polymers to explore multi-material 3D composite structures, from tissues to novel biocompatible materials.
INVIVO provides three types of printing technologies with a comprehensive temperature control from -5 to 350C:
- Syringe dispenser (and print bed): -5 to 80C
- Filament extruder: RT to 250C
- Hot-melt pneumatic dispenser: RT to 350
INVIVO’s unique features include
- UV / LED curing: 365/395/405/450/460nm, automatic on/off
- LED light on/off (to enable a pitch black chamber for photo-sensitive materials)
- 48, 96-well, microscope slide chamber, 35mm dish printing
- Able to adjust Z-leveling and load/unloading while printing is in progress
- Customizable syringe volume: 10mL (default), 3mL / 1mL
- INVIVO-specific slicing software with 40+ process parameters open to the user for maximum flexibility in print quality control
Name: Heon Ju Lee, Ph.D
Position: Managing Director
Phone Number: +82 2 867 0182
Name: Sean Seonwoo, MS
Position: Project Manager
Phone Number: +82 10 8682 2811
SunP International Inc.
Founded in 2014, SunP Biotech is a world-leading high-tech company specialized in 3D Bioprinting and manufacturing of advanced bioprinting products. Based on more than 20 years of research and development experience as well as the company proprietary technology, SunP is strived to developing innovative 3D bioprinting systems, novel bioinks and advanced multi-cellular tissue models for application to personalized tissue engineering and cancer treatment, medical devices, drug testing and new drug discovery.
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- Cell Printing:
Tower Series: ALPHA-CPT1 (Up to 4-electrical nozzles scaffolds/cell printing system, crosslinking by temperature, UV or ions)
Desktop Series: SUNP-BIOMAKER (Up to 2-electrical nozzles desktop scaffolds/cell printing system, opt to multi printhead modules)
Bone Printing: Tower Series: ALPHA-BP11 (specialty in multi-level pores scaffolds printing, with unparalleled low-temperature controlled technique for better bone regeneration)
- Cell Printing:
|Bioinks||Tumor Cells||Stem Cells||Interstitial Cells||Cartilage||Bone||Skin||Liver||Sacrificial Materials|
|Gelatin and Alginate||√||√||√||√||√|
Printing Services and Technical Consulting
- Printing Services:
Disease models, drug testing models and cellular tissue engineering models;
Design, optimization and printing of 3D scaffolds and cellular structures；
Characterization of printed cell models and novel bioinks
- Contract Research:
Customized solution provider for engineering and printing;
Development of novel bioinks
T&R Biofab Co. Ltd.
T&R Biofab is a tissue engineering company which has experienced a rapid growth with our 3D bioprinting platform technology. We aim to claim the title for the best biomedical engineering company in the world that is capable of printing human organs and tissues in vitro for clinical transplantation. We strive to cure the world of life’s pain and realize its value through our research.
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We develop and manufacture bioresorbable scaffolds, organoids, and 3D cell therapy based on our unique 3D bioprinting platform technology, such as decellularized ECM-derived bioinks and 3D bioprinters.
- T&R Biofab’s 3D printer(3DXPrinter) allows for printing of various materials, including biodegradable polymers, ceramics and cell-laden bioink. Our printers are well suited for the printing of medical devices for transplantation, tissue regeneration, hydrogels, and organoid models.
Bioink (deCelluid™-skin, bone, cartilage)
- Made from porcine decellularized extracellular matrix (dECM), deCelluid™ is used to provide a favorable environment for cells (especially stem cells) to grow in conditions which are biomimetic containing the natural bioactive molecules found in native tissue.
- A bioresorbable scaffold is a medical device for assisting reconstruction and regeneration of defective or damaged tissue. Our 3D printed scaffolds feature the use of a porous structure made from biocompatible polymers, which allows for the infiltration of native tissues into the implant which naturally degrades over time.
- We are developing 3D printed organoids which can solve ethical and scientific problems associated with animals testing. Artificial models of human organs and tissues made through a mixed approach of 3D printing and stem cell culturing techniques. Organoids are a product which can be used as an alternative to animal testing or as a drug screening system for novel pharmaceuticals. (currently under development)
3D Cell Therapy
- We are also developing 3D printed cell therapeutic devices such as a pre-vascularized cardiac patch and artificial blood vessels. 3D printed cell patch or artificial tissue can enhance the therapeutic efficacy for various diseases. The spatial patterning of multiple cells can improve cell-to-cell interactions and promotes increased functionality of the printed cells. (currently under development)
- 3DXPrinter (3D Bioprinter), deCelluid™-skin, bone, cartilage (specific tissue derived bioink), TnR Mesh (Bioresorbable scaffold)
tel: + 82-31-431-3344
The continuing trend towards miniaturization delivers ever more compact and powerful products. The requirements placed on microparts in the production sector, as well as academic and industrial research are constantly rising. To keep up with these developments new manufacturing standards are needed. We establish high-resolution 3D-printing as a supplement to established tooling-based fabrication methods.
UpNanos novel and innovative 3D-printing process enables economical production of polymeric microparts with highest precision and resolution in the 100 nm range, without exceeding tolerances. The lead product NanoOne combines the precision of 2-photon polymerization with unmatched throughput. And thus, economic efficiency!
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True to the slogan ‟small, fast, powerful”
small high-resolution desktop printing system with sub-micron resolution
With 700x580x610 mm the NanoOne printing system is not only suitable for production halls but also fits in the narrowest lab, enabling economic production of polymer parts from micro to mesoscale.
fast up to a 100 times higher throughput for short production cycles
UpNanos patented printing process combines highest resolution with unmatched throughput for the first time, enabling new application possibilities and production approaches.
powerful high power laser for mesoscale and biological applications
Despite the high power the laser is gentle to cells, enabling not only the fabrication of precise and complex mesoscale structures but also bioprinting in the presence of living cells.
UpNano aims to become technology leader in the field of high-resolution 3D-printing for both prototyping and industrial applications, providing its customers with comprehensive solutions from a single source. Apart from the advanced 3D-printing system NanoOne operated via a highly intuitive and user-friendly software, the product portfolio encompasses a range of process-matching materials, from classical photopolymers, to hybrid organic-inorganic materials and hydrogels for biomedical applications.
The optimized process along with the advanced biocompatible materials, for the first time enables high-resolution 3D-printing with living cells and realization of tissue engineering scaffolds of relevant size. Thereby the cells can already be pre-mixed into the material before 3D-printing or be seeded onto a ready structure. These innovations benefit the areas of cell and tissue research and will facilitate efficiency and reproducibility of the experiments potentially revolutionizing pre-clinical research.
Wake Forest Institute for Regenerative Medicine
The Wake Forest Institute for Regenerative Medicine is recognized as an international leader in translating scientific discovery into clinical therapies. Its physicians and scientists were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this team is working to engineer replacement tissues and organs and develop healing cell therapies for more than 40 different areas of the body.
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With the goal of speeding the process of discovery, the institute is designed for collaboration – scientists in the fields of biomedical and chemical engineering, cell and molecular biology, biochemistry, physiology, materials science, nanotechnology, genomics, proteomics, surgery and medicine work side by side. The institute has invested in a Good Manufacturing Practices/Good Tissue Practices facility which operates under guidelines of the U.S. Food and Drug Administration to hasten the delivery of technologies to patients. Several regenerative medicine therapies developed by the institute scientists are already in patients, and others in the pipeline.
Institute research focuses on a wide range of engineered replacement tissues and restorative cell therapies with the aim of making a lasting impact on conditions ranging from diabetes to heart disease. Projects range from engineered heart valves and blood vessels to technology to print skin cells directly on burns. The institute is working to apply the science of regenerative medicine to battlefield injuries through leading a $75-million federally funded project, the Armed Forces Institute for Regenerative Medicine II.
The institute offers a full range of educational and training programs to expose and educate students, teachers, scientists and the public. These programs highlight career opportunities in the biosciences while attracting the next generation of talent in the field of regenerative medicine. Programs include the annual Regenerative Medicine Essentials Course, High School Summer Research Exposure Program, Visiting International Scholars Program, Summer Scholars Program and National Institutes of Health Predoctoral Training Program.
More than 450 scientists collaborate on regenerative medicine research at the institute, the largest in the world. The institute is part of Wake Forest University and is located in the Innovation Quarter in downtown Winston-Salem, NC. Through partnerships and collaborations with many regenerative medicine centers internationally, the institute, which is driven by the urgent needs of patients, is making a global difference in the world of regenerative medicine.
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